The synthesis and evaluation of dihydroquinazolin-4-ones and quinazolin-4-ones as thyroid stimulating hormone receptor agonists
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منابع مشابه
The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.
We herein describe the rapid synthesis of a diverse set of dihydroquinazolin-4-ones and quinazolin-4-ones, their biological evaluation as thyroid stimulating hormone receptor (TSHR) agonists, and SAR analysis. Among the compounds screened, 8b was 60-fold more potent than the hit compound 1a, which was identified from a high throughput screen of over 73,000 compounds.
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Series of 4H-3,1-benzoxazin-4-ones and 3H-quinazolin-4-ones with phenoxy-methyl substituents were rationally designed and easily synthesized via one-pot N-acylation/ring closure reactions of anthranilic acids with 2-phenoxyacetyl chlorides to yield the 4H-3,1-benzoxazin-4-ones, and subsequently substituted with amino derivatives to obtain the 3H-quinazolin-4-ones. The herbicidal evaluation was ...
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Synthesis of 2,3-dihydroquinazolin-4(1H)-ones using H3BO3/montmorillonite K10 (H3BO3/mont K10) catalyst has been reported. H3BO3/mont K10 and H3BO3/mont K30 have been prepared and used as catalysts in the reaction between anthranilamide and benzaldehyde to prepare 2-phenyl...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2011
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c1md00145k